The bubonic plague, caused by the bacterium Yersinia pestis, is a serious infectious disease historically known as the “Black Death.” Although rare today, it remains a potentially fatal illness if not treated promptly. Understanding how to treat bubonic plague effectively is crucial for survival and recovery.
Early Recognition and Diagnosis
Symptoms of bubonic plague typically develop 2 to 6 days after exposure and include sudden fever, chills, headache, fatigue, and notably, painful swollen lymph nodes called buboes, often found in the groin, armpits, or neck. Diagnosis is confirmed by laboratory testing of blood, lymph node fluid, or sputum to detect Y. pestis bacteria.
Immediate Treatment Is Critical
Prompt initiation of antibiotic therapy within 24 hours of symptom onset is essential to prevent severe complications or death. Without treatment, bubonic plague can progress to septicemic or pneumonic plague, which are often fatal.
Must Read-Bubonic Plague 2025: Arizona Reports Rare and Fatal Case
Antibiotic Therapy
Several classes of antibiotics are highly effective against bubonic plague. The choice of antibiotic and route of administration (oral or intravenous) depends on the severity of illness and patient-specific factors such as age and allergies.
- First-line antibiotics include:
- Gentamicin (aminoglycoside) — widely used and effective, administered IV or IM.
- Streptomycin — historically the gold standard but less commonly used now.
- Fluoroquinolones such as ciprofloxacin and moxifloxacin — effective alternatives, with moxifloxacin approved for adults.
- Doxycycline — a tetracycline antibiotic used especially in uncomplicated cases or as an alternative.
- Other options include chloramphenicol, particularly in cases involving meningitis or severe systemic infection.
Treatment duration typically ranges from 10 to 14 days, but may be extended if symptoms persist.
Supportive Care
In addition to antibiotics, supportive treatments such as oxygen therapy, intravenous fluids, and respiratory support may be necessary depending on the patient’s condition.
Infection Control and Prevention
Patients suspected of having plague should be isolated to prevent spread, especially if pneumonic plague is suspected. Close contacts may receive prophylactic antibiotics to prevent infection.
Prognosis
With rapid and appropriate treatment, the survival rate for bubonic plague exceeds 90%, and symptoms often improve within one to two weeks. However, untreated plague has a high mortality rate of 40% to 60%.